Background: Lactate dehydrogenase (LDH) is a group of oxidoreductase isoenzymes
catalyzing the reversible reaction between pyruvate and lactate. The five isoforms of this …

Where are we in our understanding of enzyme catalysis? The gloomier view is that protein
structure and enzyme function are the finely balanced end-products of many weak …

Simple Summary Almost a century ago, Nobel Prize laureate Otto Warburg realized that
cancer cells consumed much more glucose than normal cells and also produced large …

Malate dehydrogenases are widely distributed and alignment of the amino acid sequences
show that the enzyme has diverged into 2 main phylogenetic groups. Multiple amino acid …

Conspectus As is well-known, enzymes are proteins designed to accelerate specific life
essential chemical reactions by many orders of magnitude. A folded protein is a highly …

Department of Biochemistry and Biophysics and Graduate Group in Biophysics, University of
California, San Francisco, California 94143-0448, and Department of Molecular and Cell …

Three variations to the structure of the nicotinamide adenine dinucleotide (NAD)-dependent
L-lactate dehydrogenase from Bacillus stearothermophilus were made to try to change the …

The crystal structure of flavocytochrome b 2 has been solved at 3.0 Å resolution by the
method of multiple isomorphous replacement with anomalous scattering. Area detector data …

Abstract The Global Positioning System has been used to measure the relative
displacements of fifteen monuments in a hundred-year-old triangulation network spanning …

Conspectus This Account describes the use of molecular dynamics (MD) simulations to
reveal how mutations alter the structure and organization of enzyme active sites. As …