S100A6: molecular function and biomarker role

Y Wang, X Kang, X Kang, F Yang - Biomarker Research, 2023 - Springer
S100A6 (also called calcyclin) is a Ca2+-binding protein that belongs to the S100 protein
family. S100A6 has many functions related to the cytoskeleton, cell stress, proliferation, and …

Genomics of adaptive evolution in the woolly mammoth

D Díez-del-Molino, M Dehasque, JC Chacón-Duque… - Current Biology, 2023 - cell.com
Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct
organisms. However, the identification of species-specific fixed genetic variants requires the …

[HTML][HTML] Recent progress in hair follicle stem cell markers and their regulatory roles

YZ Xing, HY Guo, F Xiang, YH Li - World Journal of Stem Cells, 2024 - ncbi.nlm.nih.gov
Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population.
They can periodically give rise to new HFs and even regenerate the epidermis and …

Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

Q Zhao, Y Zheng, D Zhao, L Zhao, L Geng, S Ma… - Protein & …, 2023 - academic.oup.com
Hair loss affects millions of people at some time in their life, and safe and efficient treatments
for hair loss are a significant unmet medical need. We report that topical delivery of quercetin …

Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis

G Chovatiya, KN Li, J Li, S Ghuwalewala… - Nature …, 2023 - nature.com
Vascular endothelial (VE)-cadherin is a well-recognized endothelial cell marker. One of its
interacting partners, the TGF-β receptor Alk1, is essential in endothelial cells for adult skin …

Blood endothelial ALK1‐BMP4 signaling axis regulates adult hair follicle stem cell activation

KN Li, G Chovatiya, DY Ko, S Sureshbabu… - The EMBO …, 2023 - embopress.org
Blood vessels can play dual roles in tissue growth by transporting gases and nutrients and
by regulating tissue stem cell activity via signaling. Correlative evidence implicates skin …

Single-cell transcriptomics reveals the molecular anatomy of sheep hair follicle heterogeneity and wool curvature

S Wang, T Wu, J Sun, Y Li, Z Yuan… - Frontiers in Cell and …, 2021 - frontiersin.org
Wool is the critical textile raw material which is produced by the hair follicle of sheep.
Therefore, it has important implications to investigate the molecular mechanism governing …

LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

KM Polkoff, NK Gupta, AJ Green, Y Murphy, J Chung… - Scientific Reports, 2022 - nature.com
Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche,
have remarkable regenerative capacity throughout hair cycling, and display fate plasticity …

iPSC-based approach for human hair follicle regeneration

C Vatanashevanopakorn… - Frontiers in Cell and …, 2023 - frontiersin.org
Hair follicles (HFs) are a multifunctional structure involved in physical protection,
thermoregulation, sensational detection, and wound healing. Formation and cycling of HFs …

A kaleidoscope of keratin gene expression and the mosaic of its regulatory mechanisms

EP Kalabusheva, AS Shtompel, AL Rippa… - International Journal of …, 2023 - mdpi.com
Keratins are a family of intermediate filament-forming proteins highly specific to epithelial
cells. A combination of expressed keratin genes is a defining property of the epithelium …