Squalene is a natural lipid belonging to the terpenoid family and a precursor of cholesterol
biosynthesis. It is synthesized in humans and also in a wide array of organisms and …

Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

The effective treatment of malignant brain glioma is hindered by the poor transport across
the blood–brain barrier (BBB) and the low penetration across the blood-tumor barrier (BTB) …

Genetic or pharmacological alteration of the activity of the histone deacetylase 6 (HDAC6)
induces a parallel alteration in cell migration. Using tubacin to block deacetylation of α …

Abstract Treatment with HIV-1 protease inhibitors (PI) is associated with a reduced incidence
or regression of Kaposi sarcoma (KS). Here we show that systemic administration of the PIs …

Kaposi's sarcoma (KS) is an angioproliferative disease occurring in several different clinical-
epidemiological forms that, however, share the same histological traits and are all …

The structural pharmacophore of Taxol, responsible for binding the N terminus of the β-
subunit of tubulin to arrest cell proliferation, comprises, in part, the 13-O-(N-benzoyl-3 …

Methanogens are anaerobic archaea which conserve energy by producing methane. Found
in nearly every anaerobic environment on earth, methanogens serve important roles in …

HIV protease inhibitors are antiretroviral drugs that block the enzyme required for production
of infectious viral particles. Although these agents have been designed to selectively bind to …

Anticancer agents that interfere with tubulin functions are widely used in the clinic and have
a broad spectrum of activity against both haematological malignancies and solid tumours …