[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Anti‐vascular endothelial growth factor for neovascular age‐related macular degeneration

SD Solomon, K Lindsley, SS Vedula… - Cochrane Database …, 2014 - cochranelibrary.com
Background Age‐related macular degeneration (AMD) is the most common cause of
uncorrectable severe vision loss in people aged 55 years and older in the developed world …

Age-related macular degeneration

RD Jager, WF Mieler, JW Miller - New England Journal of …, 2008 - Mass Medical Soc
Age-related macular degeneration is the leading cause of irreversible blindness in people
50 years of age or older in the developed world. This article reviews the clinical and …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease?

A Laude, PD Cackett, EN Vithana, IY Yeo… - Progress in retinal and …, 2010 - Elsevier
Neovascular age-related macular degeneration (nAMD) is the commonest cause of severe
visual impairment in older adults in Caucasian white populations. Polypoidal choroidal …

The incidence of neovascular subtypes in newly diagnosed neovascular age-related macular degeneration

JJ Jung, CY Chen, S Mrejen, R Gallego-Pinazo… - American journal of …, 2014 - Elsevier
Purpose To determine the frequency of neovascularization subtypes as determined by
fluorescein angiography (FA) alone vs FA and optical coherence tomography (OCT) grading …

Age-related macular degeneration and the complement system

S Khandhadia, V Cipriani, JRW Yates, AJ Lotery - Immunobiology, 2012 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed
world. It is a complex multifactorial disease, and despite new advances in treatment, many …

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4

GK Yeboah, ES Lobanova, RS Brush… - Journal of Lipid Research, 2021 - ASBMB
Lipids play essential roles in maintaining cell structure and function by modulating
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …

Cigarette smoking and the natural history of age-related macular degeneration: the Beaver Dam Eye Study

CE Myers, BEK Klein, R Gangnon, TA Sivakumaran… - Ophthalmology, 2014 - Elsevier
Purpose To examine the association of current cigarette smoking and pack-years smoked
with the incidence and progression of age-related macular degeneration (AMD) and to …

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics

MB Gorin - Molecular aspects of medicine, 2012 - Elsevier
Age-related macular degeneration (AMD) is a common condition among the elderly
population that leads to the progressive central vision loss and serious compromise of …