The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Adoptive transfer of antigen-specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in some patients. Both the number of …

Lactation is critical to infant short-term and long-term health and protects mothers from
breast cancer, ovarian cancer and type 2 diabetes mellitus. The mammary gland is a …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs).
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …

Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Extracellular proteins bound to cell-surface receptors can change nuclear gene expression
patterns in minutes, with far-reaching consequences for development, cell growth and …