Advances in passively driven microfluidics and lab-on-chip devices: A comprehensive literature review and patent analysis

V Narayanamurthy, ZE Jeroish, KS Bhuvaneshwari… - RSC …, 2020 - pubs.rsc.org
The development of passively driven microfluidic labs on chips has been increasing over the
years. In the passive approach, the microfluids are usually driven and operated without any …

Recent progress in translational engineered in vitro models of the central nervous system

P Nikolakopoulou, R Rauti, D Voulgaris, I Shlomy… - Brain, 2020 - academic.oup.com
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

JS Park, BK Lee, GS Jeong, JK Hyun, CJ Lee, SH Lee - Lab on a Chip, 2015 - pubs.rsc.org
There has been a growing need for in vitro models of neurodegenerative diseases such as
Alzheimer's disease that would enable a better understanding of etiology and faster …

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

GT Vladisavljević, N Khalid, MA Neves… - Advanced drug delivery …, 2013 - Elsevier
Microfluidics is an emerging and promising interdisciplinary technology which offers
powerful platforms for precise production of novel functional materials (eg, emulsion …

Biological applications of microfluidic gradient devices

S Kim, HJ Kim, NL Jeon - Integrative Biology, 2010 - academic.oup.com
Molecular gradients play an important role in diverse physiological and pathological
phenomena such as immune response, wound healing, development and cancer …

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

SA Lee, E Kang, J Ju, DS Kim, SH Lee - Lab on a Chip, 2013 - pubs.rsc.org
We have developed a three-dimensional (3D) liver-on-a-chip to investigate the interaction of
hepatocytes and hepatic stellate cells (HSCs) in which primary 3D hepatocyte spheroids …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Microfluidic evaporation, pervaporation, and osmosis: from passive pumping to solute concentration

P Bacchin, J Leng, JB Salmon - Chemical Reviews, 2021 - ACS Publications
Evaporation, pervaporation, and forward osmosis are processes leading to a mass transfer
of solvent across an interface: gas/liquid for evaporation and solid/liquid (membrane) for …

Microfluidic organoids-on-a-chip: Quantum leap in cancer research

F Duzagac, G Saorin, L Memeo, V Canzonieri… - Cancers, 2021 - mdpi.com
Simple Summary Organoids, also known as self-organized 3D organ-like clusters, represent
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …

In vitro microfluidic models for neurodegenerative disorders

T Osaki, Y Shin, V Sivathanu… - Advanced healthcare …, 2018 - Wiley Online Library
Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …