Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Abstract RNA Polymerase (Pol) I produces ribosomal (r) RNA, an essential component of the
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …

Although well studied in vitro, the in vivo functions of G-quadruplexes (G4-DNA and G4-
RNA) are only beginning to be defined. Recent studies have demonstrated enrichment for …

The nuclear ribosomal locus coding for the large subunit is represented in tandem arrays in
the plant genome. These consecutive gene blocks, consisting of several regions, are widely …

The expression of genes, both coding and noncoding, can be significantly influenced by
RNA structural features of their corresponding transcripts. There is by now mounting …

Transcriptional silencing in Saccharomyces cerevisiae occurs at several genomic sites
including the silent mating-type loci, telomeres, and the ribosomal DNA (rDNA) tandem …

The nucleolus is the most obvious and clearly differentiated nuclear sub-compartment. It is
where ribosome biogenesis takes place, but it is becoming clear that the nucleolus also has …

Ribosome assembly is required for cell growth in all organisms. Classic in vitro work in
bacteria has led to a detailed understanding of the biophysical, thermodynamic, and …

The formation of eukaryotic ribosomes is a multistep process that takes place successively in
the nucleolar, nucleoplasmic and cytoplasmic compartments,,,. Along this pathway, multiple …

SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome
biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated …