Thapsigargin is the most widely used inhibitor of the ubiquitous sarco-endoplasmic
reticulum Ca 2+-ATPases in mammalian cells. Over the past ten years, this guaianolide …

The skin irritating principle from Thapsia garganica was isolated, named thapsigargin and
the structure elucidated. By inhibiting the sarco/endoplasmic reticulum Ca 2+ ATPase …

Although many types of ancient bacteria and archea rely on hydrogen sulfide (H2S) for their
energy production, eukaryotes generate ATP in an oxygen-dependent fashion. We …

Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat
hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as …

The depletion of an inositol 1, 4, 5-trisphosphate-sensitive intracellular Ca 2+ pool has been
proposed to be the signal for Ca 2+ entry in agonist-activated cells. Consistent with this idea …

Hormones, neurotransmitters, growth factors, and other extracellular stimuli communicate
with their target cells through a specific stimulation of surface receptors that further transduce …

Thapsigargin, a sesquiterpene lactone with potent irritant and tumour-promoting activities,
stimulates a rapid (within 15 s) transient increase in intracellular [Ca2+] in the NG115-401L …

The SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) is probably the most
extensively studied membrane protein transporter. There is a vast array of diverse inhibitors …

As one of the largest groups of secondary plant metabolites, sesquiterpene lactones (STL)
possess a broad variety of conspicuous biological activities directed towards all types of …

Total syntheses of the complex, highly oxygenated sesquiterpenes thapsigargin (1) and
nortrilobolide (2) are presented. Access to analogues of these promising bioactive natural …