Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related
clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature …

Clonal hematopoiesis (CH) is defined as a single hematopoietic stem/progenitor cell
(HSPC) gaining selective advantage over a broader range of HSPCs. When linked to …

Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal
hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), defined as the presence of a
somatic mutation in the peripheral blood at a variant allele frequency (VAF)≥ 2%, affects at …

Highlights•The clinical implications of clonal hematopoiesis in the cancer setting are
reviewed.•The biologic interplay between clonal hematopoiesis and development of solid …

The mammalian DNA methylation landscape is established and maintained by the
combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) …

Over the past few years, we have gained a deeper understanding of clonal hematopoiesis of
indeterminate potential (CHIP), especially with regard to the epidemiology, clinical …

The epigenetic memory stored in the dynamic modifications, such as base modifications of
cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes …