The contribution of microglia to neuroinflammation in Parkinson's disease

K Badanjak, S Fixemer, S Smajić, A Skupin… - International Journal of …, 2021 - mdpi.com
With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Microglia-containing human brain organoids for the study of brain development and pathology

W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

MJ Dolan, M Therrien, S Jereb, T Kamath… - Nature …, 2023 - nature.com
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

DS Park, T Kozaki, SK Tiwari, M Moreira… - Nature, 2023 - nature.com
Microglia are specialized brain-resident macrophages that arise from primitive macrophages
colonizing the embryonic brain. Microglia contribute to multiple aspects of brain …

Microglial amyloid beta clearance is driven by PIEZO1 channels

H Jäntti, V Sitnikova, Y Ishchenko… - Journal of …, 2022 - Springer
Background Microglia are the endogenous immune cells of the brain and act as sensors of
pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's …

Expression of the transcription factor PU. 1 induces the generation of microglia-like cells in human cortical organoids

B Cakir, Y Tanaka, FR Kiral, Y Xiang… - Nature …, 2022 - nature.com
Microglia play a role in the emergence and preservation of a healthy brain
microenvironment. Dysfunction of microglia has been associated with neurodevelopmental …

The role of gamma oscillations in central nervous system diseases: Mechanism and treatment

A Guan, S Wang, A Huang, C Qiu, Y Li, X Li… - Frontiers in cellular …, 2022 - frontiersin.org
Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …

Microglial contribution to the pathology of neurodevelopmental disorders in humans

R Matuleviciute, ET Akinluyi, TAO Muntslag… - Acta …, 2023 - Springer
Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …

[HTML][HTML] Microglia-mediated synaptic pruning as a key deficit in neurodevelopmental disorders: Hype or hope?

A Mordelt, LD de Witte - Current Opinion in Neurobiology, 2023 - Elsevier
There is a consensus in the field that microglia play a prominent role in neurodevelopmental
processes like synaptic pruning and neuronal network maturation. Thus, a current …

Human iPSC-derived glia models for the study of neuroinflammation

N Stöberl, E Maguire, E Salis, B Shaw… - Journal of …, 2023 - Springer
Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …