Higher accessibility and decreasing costs of next generation sequencing (NGS), availability
of commercial kits, and development of dedicated analysis pipelines, have allowed an …

Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …

Metagenomic next-generation sequencing (mNGS) is an untargeted technique for
determination of microbial DNA/RNA sequences in a variety of sample types from patients …

Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug
resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been …

Next-generation sequencing (NGS) is increasingly used for HIV-1 drug resistance
genotyping. NGS methods have the potential for a more sensitive detection of low …

Background We investigated the efficacy of a switch to dolutegravir plus lamivudine in
aviremic individuals without evidence of persistent lamivudine resistance-associated …

Conventional HIV drug resistance (HIVDR) genotyping utilizes Sanger sequencing (SS)
methods, which are limited by low data throughput and the inability of detecting low …

Background Pre-treatment HIV-drug-resistance (PDR) to WHO-recommended 1st-line non-
nucleoside reverse transcriptase inhibitors (NNRTI)-based antiretroviral treatment (ART) is …

Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …

The course of Human Immunodeficiency Virus type 1 (HIV) infection is a dynamic interplay in
which both host and viral genetic variation, among other factors, influence disease …