Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the
treatment of a variety of human diseases. Recent advances in developing clinically …

Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large
number of gene therapy clinical trials, which have demonstrated their strong safety profile …

The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which
is gradually depleted during a woman's reproductive lifespan, resulting in menopause …

Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles,
is an important regulator of folliculogenesis and follicle development. Treatment with …

Adult-type granulosa cell tumor is a clinically and molecularly unique subtype of ovarian
cancer. These tumors originate from the sex cord stromal cells of the ovary and represent 3 …

Aberrant expression of viral-like repeat elements is a common feature of epithelial cancers,
and the substantial diversity of repeat species provides a distinct view of the cancer …

Cancer-associated mesothelial cells (CAMCs) in the tumor microenvironment are thought to
promote growth and immune evasion. We find that, in mouse and human ovarian tumors …

PG545 (Pixatimod) is a highly sulfated small molecule known for its ability to inhibit
heparanase and disrupt signaling mediated by heparan-binding-growth factors (HB-GF) …

Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and
have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic …

Ovarian cancer is the most lethal gynecological malignancy in developed countries. This is
due to the lack of specific symptoms that hinder early diagnosis and to the high relapse rate …