Translation‐coupled mRNA quality control mechanisms
L Monaghan, D Longman, JF Cáceres - The EMBO Journal, 2023 - embopress.org
Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
Mechanism and regulation of the nonsense-mediated decay pathway
N Hug, D Longman, JF Cáceres - Nucleic acids research, 2016 - academic.oup.com
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
V Boehm, S Kueckelmann, JV Gerbracht… - Nature …, 2021 - nature.com
Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-
mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD …
mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD …
Nonsense-mediated mRNA decay begins where translation ends
ED Karousis, O Mühlemann - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Nonsense-mediated mRNA decay (NMD) is arguably the best-studied eukaryotic
messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the …
messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the …
Nonsense-mediated mRNA decay—mechanisms of substrate mRNA recognition and degradation in mammalian cells
C Schweingruber, SC Rufener, D Zünd… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …
coupled quality control system that recognizes and degrades aberrant mRNAs with …
Nonsense‐mediated mRNA decay: novel mechanistic insights and biological impact
ED Karousis, S Nasif… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …
N-and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5: SMG-7 during NMD
Y Okada-Katsuhata, A Yamashita… - Nucleic acids …, 2012 - academic.oup.com
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and
degrades mRNAs containing premature termination codons (PTCs). SMG-1-mediated Upf1 …
degrades mRNAs containing premature termination codons (PTCs). SMG-1-mediated Upf1 …
Rules that govern UPF1 binding to mRNA 3′ UTRs
T Kurosaki, LE Maquat - Proceedings of the National …, 2013 - National Acad Sciences
Nonsense-mediated mRNA decay (NMD), which degrades transcripts harboring a
premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1) …
premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1) …
Regulation of nonsense‐mediated mRNA decay
L Huang, MF Wilkinson - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) is a highly conserved pathway that was originally
identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring …
identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring …
Mechanism, factors, and physiological role of nonsense-mediated mRNA decay
T Fatscher, V Boehm, NH Gehring - Cellular and Molecular Life Sciences, 2015 - Springer
Nonsense-mediated mRNA decay (NMD) is a translation-dependent, multistep process that
degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a …
degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a …