The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic
and preventative strategies to attenuate complications of this debilitating disease. Diabetic …

Cardiac fibrosis is one of the main characteristics of diabetic cardiomyopathy and manifests
excessive accumulation of extracellular matrix proteins in the heart. Several signaling …

Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and
muscle function in the lower limbs. A skeletal muscle myopathy characterized by …

Providing a conducive microenvironment is critical to increase survival of transplanted stem
cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac …

Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …

Necroptosis is one of a regulated programmed death mode, fibrosis is closely related with
cell death. It has been reported that inhibition of necroptosis can play the protective role in …

A chronic metabolic illness, type 2 diabetes (T2D) is a polygenic and multifactorial
complicated disease. With an estimated 463 million persons aged 20 to 79 having diabetes …

Patients with diabetes have an increased risk of developing heart failure, preceded by (often
asymptomatic) cardiac abnormalities, collectively called diabetic cardiomyopathy (DC) …

Diabetes mellitus (DM) is an important lifestyle disease. Type 2 diabetes is one of the prime
contributors to cardiovascular diseases (CVD) and diabetic cardiomyopathy (DbCM) and …