BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases

G Xiong, K Zhang, Y Ma, Y Song, W Zhang… - Frontiers in …, 2023 - frontiersin.org
Subcellular organelles dysfunction is implicated in various diseases, including metabolic
diseases, neurodegenerative diseases, cancer, and cardiovascular diseases. BAM15, a …

Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome

BG Dos Santos, NF Brisnovali… - Biochemical Journal, 2024 - portlandpress.com
Mild uncoupling of oxidative phosphorylation is an intrinsic property of all mitochondria,
allowing for adjustments in cellular energy metabolism to maintain metabolic homeostasis …

Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells

A Ruiz-Pino, A Goncalves-Ramírez… - … -European Journal of …, 2024 - Springer
Hyperglucagonemia has been implicated in the pathogenesis of type 2 diabetes (T2D). In
contrast to β-cells, studies on the function of the pancreatic α-cell in T2D are scarce …

Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice

M Beretta, Y Dai, EM Olzomer, CS Vancuylenburg… - Diabetes, 2024 - Am Diabetes Assoc
Excess body fat is a risk factor for metabolic diseases and is a leading preventable cause of
morbidity and mortality worldwide. There is a strong need to find new treatments that …

Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice

SY Chen, M Beretta, EM Olzomer… - … et biophysica acta …, 2023 - pmc.ncbi.nlm.nih.gov
Metabolic disorders such as type 2 diabetes, fatty liver disease, hyperlipidemia, and obesity
commonly co-occur but clinical treatment options do not effectively target all disorders …

Beneficial effects of MGL‐3196 and BAM15 combination in a mouse model of fatty liver disease

M Zhou, C Li, FL Byrne, CS Vancuylenburg… - Acta …, 2024 - Wiley Online Library
Abstract Background and Aim Metabolic dysfunction‐associated steatohepatitis (MASH) is a
metabolic disorder with limited treatment options. The thyroid hormone receptor (THR)‐β …

Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice

SY Chen, AJ Telfser, EM Olzomer… - Clinical …, 2024 - portlandpress.com
Semaglutide is an anti-diabetes and weight loss drug that decreases food intake, slows
gastric emptying, and increases insulin secretion. Patients begin treatment with low-dose …

[HTML][HTML] Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice

SY Chen, M Beretta, EM Olzomer… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Metabolic disorders such as type 2 diabetes, fatty liver disease, hyperlipidemia, and obesity
commonly co-occur but clinical treatment options do not effectively target all disorders …

Supplementation with Jatobá-do-cerrado flour (Hymenaea stigonocarpa Mart.) decreases hypothalamic inflammation and improves obesity parameters in rats on a …

AA da Silva, A Rocha-Gomes, ÍG Reis… - Journal of …, 2023 - Elsevier
To evaluate the impact of jatobá-do-cerrado flour on nutritional, inflammatory, and oxidative
stress markers, an study was conducted using male Wistar rats. These animals were …

Exploring the Effects of Dietary Interventions on Gut Microbiota Dynamics in Obesity and its Health Implications in C57Bl/6 Male Mice

S Mahmoodianfard - 2024 - ruor.uottawa.ca
Gut microbiota is increasingly recognized as a promising target for therapeutic interventions
aimed at preventing and managing obesity and associated dysfunctions. Recently, there has …