[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
The sequences of 150,119 genomes in the UK Biobank
BV Halldorsson, HP Eggertsson, KHS Moore… - Nature, 2022 - nature.com
Detailed knowledge of how diversity in the sequence of the human genome affects
phenotypic diversity depends on a comprehensive and reliable characterization of both …
phenotypic diversity depends on a comprehensive and reliable characterization of both …
Cohort profile update: the HUNT study, Norway
BO Åsvold, A Langhammer, TA Rehn… - International journal …, 2023 - academic.oup.com
The Trøndelag Health Study (the HUNT Study) is a population-based cohort study of the
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
Mexican Biobank advances population and medical genomics of diverse ancestries
Latin America continues to be severely underrepresented in genomics research, and fine-
scale genetic histories and complex trait architectures remain hidden owing to insufficient …
scale genetic histories and complex trait architectures remain hidden owing to insufficient …
Novel genes and sex differences in COVID-19 severity
R Cruz, S Diz-de Almeida… - Human Molecular …, 2022 - academic.oup.com
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …
Parental relatedness through time revealed by runs of homozygosity in ancient DNA
Parental relatedness of present-day humans varies substantially across the globe, but little
is known about the past. Here we analyze ancient DNA, leveraging that parental relatedness …
is known about the past. Here we analyze ancient DNA, leveraging that parental relatedness …
Genotyping and population characteristics of the China Kadoorie Biobank
RG Walters, IY Millwood, K Lin, DS Valle, P McDonnell… - Cell Genomics, 2023 - cell.com
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
From Mendel to quantitative genetics in the genome era: the scientific legacy of WG Hill
The quantitative geneticist WG ('Bill') Hill, awardee of the 2018 Darwin Medal of the Royal
Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on 17 …
Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on 17 …
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls
The ability to precisely edit the genome of human induced pluripotent stem cell (iPSC) lines
using CRISPR/Cas9 has enabled the development of cellular models that can address …
using CRISPR/Cas9 has enabled the development of cellular models that can address …
Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
MA Stoffel, SE Johnston, JG Pilkington… - Nature …, 2021 - nature.com
Inbreeding depression is ubiquitous, but we still know little about its genetic architecture and
precise effects in wild populations. Here, we combine long-term life-history data with 417 K …
precise effects in wild populations. Here, we combine long-term life-history data with 417 K …