The methylation effect in medicinal chemistry

EJ Barreiro, AE Kümmerle, CAM Fraga - Chemical reviews, 2011 - ACS Publications
The monovalent methyl group is derived from methane through the removal of a hydrogen
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …

Toxin-producing cyanobacteria in freshwater: A review of the problems, impact on drinking water safety, and efforts for protecting public health

MY Cheung, S Liang, J Lee - Journal of Microbiology, 2013 - Springer
Cyanobacteria have adapted to survive in a variety of environments and have been found
globally. Toxin-producing cyanobacterial harmful algal blooms (CHABs) have been …

The state of US freshwater harmful algal blooms assessments, policy and legislation

HK Hudnell - Toxicon, 2010 - Elsevier
The incidence of harmful algal blooms (HABs) is increasing in the United States and
worldwide. HAB toxins cause a substantial but unquantified amount of human and animal …

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease

SM Sine - Physiological reviews, 2012 - journals.physiology.org
The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

[HTML][HTML] Nicotinic acetylcholine receptors in cancer: limitations and prospects

T Bele, T Turk, I Križaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2024 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate
neurotransmission. However, their widespread distribution in the human body suggests a …

Antidromic-rectifying gap junctions amplify chemical transmission at functionally mixed electrical-chemical synapses

P Liu, B Chen, R Mailler, ZW Wang - Nature communications, 2017 - nature.com
Neurons communicate through chemical synapses and electrical synapses (gap junctions).
Although these two types of synapses often coexist between neurons, little is known about …

The quantitative analysis of drug–receptor interactions: a short history

D Colquhoun - Trends in pharmacological sciences, 2006 - cell.com
Pharmacology started to develop into a real quantitative science in 1909, when AV Hill
derived the Langmuir equation in the course of his studies on nicotine and curare. A history …

[HTML][HTML] Ligand-receptor kinetics measured by total internal reflection with fluorescence correlation spectroscopy

AM Lieto, RC Cush, NL Thompson - Biophysical journal, 2003 - cell.com
Total internal reflection excitation used in combination with fluorescence correlation
spectroscopy (TIR-FCS) is a method for characterizing the dynamic behavior and absolute …

α7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway

S Trombino, A Cesario, S Margaritora, PL Granone… - Cancer Research, 2004 - AACR
This study presents data suggesting that both human mesothelioma (cell lines and human
mesothelioma biopsies) and human normal mesothelial cells express receptors for …

Effects of common anesthetics on eye movement and electroretinogram

G Nair, M Kim, T Nagaoka, DE Olson, PM Thulé… - Documenta …, 2011 - Springer
High-resolution magnetic resonance imaging (MRI) provides non-invasive images of retinal
anatomy, physiology, and function with depth-resolved laminar resolution. Eye movement …