Cytokine-mediated pathways are central to the pathogenesis of rheumatoid arthritis (RA).
The purpose of this short Opinion article is to briefly overview the roles of cytokine families in …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such
as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect …

Lactate has long been considered a “waste” by-product of cell metabolism, and it
accumulates at sites of inflammation. Recent findings have identified lactate as an active …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …

Swelling and the progressive destruction of articular cartilage are major characteristics of
rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial …

Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Metabolomics enables the profiling of large numbers of small molecules in cells, tissues and
biological fluids. These molecules, which include amino acids, carbohydrates, lipids …

Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic
disruption that may be therapeutically targetable. Among them, glucose metabolism and …

Objectives The differential diagnosis of seronegative rheumatoid arthritis (negRA) and
psoriasis arthritis (PsA) is often difficult due to the similarity of symptoms and the …