Thioredoxins are ubiquitous antioxidant enzymes that play important roles in many health-
related cellular processes. As such, the fundamental knowledge of how these enzymes work …

Significance: Redox homeostasis consists of an intricate network of reactions in which
reactive molecular species, redox modifications, and redox proteins act in concert to allow …

Protein disulfide isomerase plays a key role in catalyzing the folding of secretory proteins. It
features two catalytically inactive thioredoxin domains inserted between two catalytically …

Thiol-disulfide reactions are crucial for redox homeostasis in the cell. 1, 2 As a disulfide
oxidoreductase, thioredoxin (Trx,∼ 12 kDa) regulates a wide variety of biological molecules …

Thioredoxins (Trxs) are small oxidoreductases that are involved in redox homeostasis and
are found in large numbers in the subcellular compartments of eukaryotic plant cells …

Oxidative stress plays an important role in the modulation of several important physiological
functions. On the other side, oxidative stress is accountable for development of many …

Thiol–disulfide exchange reactions are highly reversible, displaying nucleophilic
substitutions mechanism (SN 2 type). For aliphatic, low molecular thiols, these reactions are …

Experimentalists and quantum chemists are living in a different world. A wealth of theoretical
enzymology-related publications is hardly known by experimentalists, and vice versa. Our …

Thioredoxin is ubiquitous and regulates various target proteins through disulfide bond
reduction. We report the structure of thioredoxin (HvTrxh2 from barley) in a reaction …

We have identified thioredoxins (Trx) of Malassezia sympodialis, a yeast involved in the
pathogenesis of atopic eczema, and of Aspergillus fumigatus, a fungus involved in …