Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review
Dihydropyrimidines are the most important heterocyclic ring systems which play an
important role in the synthesis of DNA and RNA. Synthetically they were synthesized using …
important role in the synthesis of DNA and RNA. Synthetically they were synthesized using …
A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …
S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …
They are widely used in a variety of pharmacological and industrial applications. Their …
The Biginelli reaction is a urea-catalyzed organocatalytic multicomponent reaction
M Puripat, R Ramozzi, M Hatanaka… - The Journal of …, 2015 - ACS Publications
The recently developed artificial force induced reaction (AFIR) method was applied to
search systematically all possible multicomponent pathways for the Biginelli reaction …
search systematically all possible multicomponent pathways for the Biginelli reaction …
Past, present and future of the Biginelli reaction: a critical perspective.
JS Sandhu - ARKIVOC: Online Journal of Organic …, 2012 - search.ebscohost.com
This review covers up to 2010 and some available references of 2011 of synthetic advances
in the Biginelli reaction, including recent mechanistic advances, new building blocks, new …
in the Biginelli reaction, including recent mechanistic advances, new building blocks, new …
Bioinspired synergistic formulation from dihydropyrimdinones and iodide ions for corrosion inhibition of carbon steel in sulphuric acid
The adsorption and corrosion inhibition behavior of three dihydropyrimidinone (DHPM)
derivatives on carbon steel in 0.5 M sulphuric acid solution is investigated in the present …
derivatives on carbon steel in 0.5 M sulphuric acid solution is investigated in the present …
Pyrimidine: An elite heterocyclic leitmotif in drug discovery‐synthesis and biological activity
Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they
constitute an important class of natural and synthetic compounds exhibiting diverse useful …
constitute an important class of natural and synthetic compounds exhibiting diverse useful …
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal …
Alzheimer's disease (AD) is multifactorial, progressive neurodegeneration with impaired
behavioural and cognitive functions. The multitarget-directed ligand (MTDL) strategies are …
behavioural and cognitive functions. The multitarget-directed ligand (MTDL) strategies are …
Design and synthesis of 2-amino-4,6-diarylpyrimidine derivatives as potent α-glucosidase and α-amylase inhibitors: structure–activity relationship, in vitro, QSAR …
In the present study, a series of 2-amino-4, 6-diarylpyrimidine derivatives was designed,
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores
A new series of achiral pyrimidine derivatives based on nifedipine-like structure was
designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones …
designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones …
Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids
Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic
agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in …
agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in …