The hypocretins/orexins: integrators of multiple physiological functions

J Li, Z Hu, L de Lecea - British journal of pharmacology, 2014 - Wiley Online Library
The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

Therapeutic implications of the choroid plexus–cerebrospinal fluid interface in neuropsychiatric disorders

D Demeestere, C Libert, RE Vandenbroucke - Brain, Behavior, and …, 2015 - Elsevier
The choroid plexus (CP) comprises an epithelial monolayer that forms an important physical,
enzymatic and immunologic barrier, called the blood–cerebrospinal fluid barrier (BCSFB). It …

Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development

A Yadav, SK Singh, D Sarkar - Peptides, 2023 - Elsevier
The orexins (OXs) were first reported in hypothalamus of rat, and they play an important role
in diverse physiological actions. The OXs consist of orexin A (OXA) and orexin B (OXB) …

Orexin-1 receptor co-localizes with pancreatic hormones in islet cells and modulates the outcome of streptozotocin-induced diabetes mellitus

E Adeghate, M Fernandez-Cabezudo, R Hameed… - PLoS …, 2010 - journals.plos.org
Recent studies have shown that orexins play a critical role in the regulation of sleep/wake
states, feeding behaviour, and reward processes. The exocrine and endocrine pancreas are …

Expression and potential role of the peptide orexin-A in prostate cancer

S Valiante, G Liguori, S Tafuri, LM Pavone… - Biochemical and …, 2015 - Elsevier
The peptides orexin-A and orexin-B and their G protein-coupled OX1 and OX2 receptors are
involved in multiple physiological processes in the central nervous system and peripheral …

Expression of orexin B and its receptor 2 in rat testis

G Liguori, LM Pavone, L Assisi, E Langella… - General and …, 2017 - Elsevier
The peptides orexin A (OxA) and orexin B (OxB) deriving from a common precursor
molecule, prepro-orexin, by proteolytic cleavage, bind the two G-coupled OX 1 and OX 2 …

The neuropeptide orexin A–search for its possible role in regulation of steroidogenesis in adult mice testes

D Joshi, SK Singh - Andrology, 2018 - Wiley Online Library
Orexin A, a hypothalamic neuropeptide, regulates food intake and sleep‐wake cycle by
binding to orexin receptor 1. Besides brain, orexin A and orexin receptor 1 are also present …

Knockdown of type 2 orexin receptor in adult mouse testis potentiates testosterone production and germ cell proliferation

P Sahoo, D Sarkar, S Sharma, A Verma, SK Naik… - Molecular and Cellular …, 2024 - Elsevier
Orexins (OXs) are neuropeptides which regulate various physiological processes. OXs exist
in two different forms, mainly orexin A (OXA) and orexin B (OXB) and their effects are …

Expression of orexin A and its receptor 1 in the human prostate

S Valiante, G Liguori, S Tafuri, R Campese… - Journal of …, 2013 - Wiley Online Library
The peptides orexin A (OXA) and orexin B, deriving from the cleavage of the precursor
molecule prepro‐orexin, bind two G‐coupled transmembrane receptors, named as receptor …

Presence, distribution and steroidogenic effect of the peptides orexin A and receptor 1 for orexins in the testis of the South American camelid alpaca (Vicugna pacos)

G Liguori, L Assisi, C Squillacioti, S Paino… - General and …, 2012 - Elsevier
The orexins A (oxA) and B are peptides discovered in the rat hypothalamus and
successively found in some peripheral organs of the mammalian body. They binds two …