Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and
non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release …

Effective reversal of tumor immunosuppression is of critical importance in cancer therapy. A
multifunctional delivery vector that can effectively deliver CRISPR‐Cas9 plasmid for β …

DNA hydrogels with unique sequence programmability on nucleic acid framework manifest
remarkable attributes, such as high payload capacities, biocompatibility and biosafety. The …

Aptamer based drug delivery systems are gaining the importance in anticancer therapy due
to their targeted drug delivery efficiency without harming the normal cells. The present work …

Discovered in 1973, nucleolin is one of the most abundant phosphoproteins of the
nucleolus. The ability of nucleolin to be involved in many cellular processes is probably …

In this article, a novel graft polymeric micelle with targeting function ground on aptamer
AS1411 was synthesized. The micelle was based on chitosan-ss-polyethylenimine-urocanic …

DNA nanostructures hold great promise for various applications due to their remarkable
properties, including programmable assembly, nanometric positional precision, and …

Background Non-small cell lung cancer (NSCLC) is the second most prevalent cause of
cancer-related fatality. Long non-coding RNAs (lncRNAs) have been observed to exercise …

Objectives: Here, a novel cruciform DNA nanostructure was developed for targeted delivery
of doxorubicin (Dox), as an anticancer agent, to lung (A549 cells) and breast (4T1 cells) …