Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Medicinal Potential of Garcinia Species and Their Compounds

BLS Espirito Santo, LF Santana, WH Kato Junior… - Molecules, 2020 - mdpi.com
Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New
Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically …

Chemical derivatization of natural products: Semisynthesis and pharmacological aspects-A decade update

S Majhi, D Das - Tetrahedron, 2021 - Elsevier
Natural products and their semisynthetic derivatives continue to be an important source of
potential drug leads. Natural products and their analogues structures possess the …

Garcinia brasiliensis fruits and its by-products: Antioxidant activity, health effects and future food industry trends–A bibliometric review

AM de Melo, FLC Almeida… - Trends in Food Science …, 2021 - Elsevier
Background Despite the diversity of Brazilian fruit production, many native species; remain
insufficiently exploited, such as Garcinia brasilienses. Scope and approach The goal of this …

Natural biflavonoids as potential therapeutic agents against microbial diseases

JC Menezes, VR Campos - Science of The Total Environment, 2021 - Elsevier
Microbes broadly constitute several organisms like viruses, protozoa, bacteria, and fungi
present in our biosphere. Fast-paced environmental changes have influenced contact of …

Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

PK Boniface, EI Ferreira - Phytotherapy Research, 2019 - Wiley Online Library
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the …

[HTML][HTML] Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage

PS Arwa, ML Zeraik, VF Ximenes… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Garcinia brasiliensis, a plant native to the Brazilian
Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract …

In vitro antioxidant properties of the biflavonoid agathisflavone

AWL Andrade, KC Machado, KC Machado… - Chemistry Central …, 2018 - Springer
Purpose Free radicals are considered as the causative agents of a variety of acute and
chronic pathologies. Natural antioxidants have drawn attention of the researchers in recent …

[HTML][HTML] Sesquiterpenoids and flavonoids from Inula viscosa induce programmed cell death in kinetoplastids

I Zeouk, I Sifaoui, A López-Arencibia… - Biomedicine & …, 2020 - Elsevier
Neglected tropical diseases such as leishmaniasis and American trypanosomiasis represent
an increasing health problem. Current treatments are not satisfactory which remains an …

[HTML][HTML] Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents

B Mendes, JR Almeida, N Vale, P Gomes… - … and Physiology Part C …, 2019 - Elsevier
Phospholipase A 2 toxins present in snake venoms interact with biological membranes and
serve as structural models for the design of small peptides with anticancer, antibacterial and …