The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Atherosclerosis is an arterial disease process characterized by the focal subendothelial
accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Efficient clearance of apoptotic cells, termed efferocytosis, critically regulates normal
homeostasis whereas defective uptake of apoptotic cells results in chronic and non …

The richened reactive oxygen species (ROS) and their derived excessive inflammation at
bone injured sites hinder osteogenesis of endosseous Ti‐based implants. Herein, anti …

The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque.
Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Macrophages represent a major immune cell population in atherosclerotic plaques and play
central role in the progression of this lipid-driven chronic inflammatory disease. Targeting …