Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …

Abstract Tumour Necrosis Factor α (TNFα), is an inflammatory cytokine produced by
macrophages/monocytes during acute inflammation and is responsible for a diverse range …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

Of the 20 amino acids, the precise function of methionine (Met) remains among the least well
understood. To establish a determining characteristic of methionine that fundamentally …

Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …

Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4
and DR5, triggers apoptosis by inducing the oligomerization of intracellular death domains …

The inflammatory cytokine tumor necrosis factor (TNF), as well as most other ligand
members of the TNF superfamily, exist both as classical soluble cytokines, but also in the …

From the beginning of research on receptors of the tumor necrosis factor (TNF) receptor
superfamily (TNFRSF), agonistic antibodies have been used to stimulate TNFRSF receptors …

TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines which induces
apoptotic cell death in a variety of tumor cell lines. It mediates its apoptotic effects through …