Glutamate serves as the dominant central nervous system (CNS) excitatory neurotransmitter,
in part by activating N-methyl-D-aspartate receptors (NMDARs). While the structure, function …

Riluzole, a glutamate release inhibitor, has been in use for the treatment of amyotrophic
lateral sclerosis for over two decades since its approval by the Food and Drug …

Approximately one-fourth of patients with essential thrombocythemia or primary
myelofibrosis carry a somatic mutation of the calreticulin gene (CALR), the gene encoding …

Cisplatin resistance remains a major problem in the treatment of lung cancer. We have
discovered that cisplatin resistant (CR) lung cancer cells, regardless of the signaling …

Platelets are the primary cellular determinants of haemostasis and pathological thrombus
formation leading to myocardial infarction and stroke. Following vascular injury or …

Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that was
initially indicated for the treatment of moderate to severe Alzheimer's disease. It is now also …

Ionotropic glutamate receptors include α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid receptors (AMPAR), kainate receptors (KAR), and N-methyl-D-aspartate receptors …

Continuous Ca2+ influx is essential to maintain intracellular Ca2+ homeostasis and its
dysregulation leads to a variety of cellular dysfunctions. In this study, we explored the …

Intracellular calcium signaling regulates diverse physiological and pathological processes.
In solid tumors, changes to calcium channels and effectors via mutations or changes in …

GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known
for their roles in the brain, but with increasing evidence for relevance in peripheral tissues …