Small molecule soluble epoxide hydrolase inhibitors in multitarget and combination therapies for inflammation and cancer
A Das Mahapatra, R Choubey, B Datta - Molecules, 2020 - mdpi.com
The enzyme soluble epoxide hydrolase (sEH) plays a central role in metabolism of bioactive
lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts …
lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts …
Movement to the clinic of soluble epoxide hydrolase inhibitor EC5026 as an analgesic for neuropathic pain and for use as a nonaddictive opioid alternative
BD Hammock, CB McReynolds, K Wagner… - Journal of medicinal …, 2021 - ACS Publications
This report describes the development of an orally active analgesic that resolves
inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts …
inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts …
CYP-derived eicosanoids: Implications for rheumatoid arthritis
M Hoxha, B Zappacosta - Prostaglandins & Other Lipid Mediators, 2020 - Elsevier
Today the role of cytochrome P450 metabolites in inflammatory rheumatic disease, such as
rheumatoid arthritis (RA) is still poorly understood. In this review we survey the current …
rheumatoid arthritis (RA) is still poorly understood. In this review we survey the current …
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease
Neuroinflammation has been increasingly recognized to play a critical role in Alzheimer's
disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid …
disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid …
Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS …
OK Favor, PS Chauhan, E Pourmand… - Frontiers in …, 2023 - frontiersin.org
Introduction Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in
NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome …
NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome …
A distinct metabolically defined central nucleus circuit bidirectionally controls anxiety-related behaviors
J Ren, CL Lu, J Huang, J Fan, F Guo… - Journal of …, 2022 - Soc Neuroscience
Anxiety disorders are debilitating psychiatric diseases that affect∼ 16% of the world's
population. Although it has been proposed that the central nucleus of the amygdala (CeA) …
population. Although it has been proposed that the central nucleus of the amygdala (CeA) …
A soluble epoxide hydrolase inhibitor, 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-Yl) urea, ameliorates experimental autoimmune encephalomyelitis
Polyunsaturated fatty acids (PUFAs) are essential FAs for human health. Cytochrome P450
oxygenates PUFAs to produce anti-inflammatory and pain-resolving epoxy fatty acids …
oxygenates PUFAs to produce anti-inflammatory and pain-resolving epoxy fatty acids …
Synthesis and properties of 1-[(3-fluoroadamantan-1-yl)methyl]-3-R-ureas and 1,1′-(alkan-1,n-diyl)bis{3-[(3-fluoroadamantan-1-yl)methyl]ureas} as promising …
DV Danilov, VS D'yachenko, VV Burmistrov… - Russian Chemical …, 2022 - Springer
A two-step procedure to synthesize (3-fluoroadamantan-1-yl) methyl isocyanate from (3-
hydroxyadamantane) acetic acid that involves fluorination with Ishikawa's reagent on the first …
hydroxyadamantane) acetic acid that involves fluorination with Ishikawa's reagent on the first …
[HTML][HTML] Soluble epoxide hydrolase inhibitor, TPPU, attenuates progression of atherosclerotic lesions and vascular smooth muscle cell phenotypic switching
SA Kim, AS Lee, HB Lee, HJ Hur, SH Lee… - Vascular Pharmacology, 2022 - Elsevier
Atherosclerosis manifests as a chronic inflammation resulting from multiple interactions
between circulating factors and various cell types in blood vessel walls. Growing evidence …
between circulating factors and various cell types in blood vessel walls. Growing evidence …
Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion
N Matin, C Fisher, TA Lansdell, BD Hammock… - …, 2021 - Wiley Online Library
Abstract Objective Parenchymal arterioles (PAs) regulate perfusion of the cerebral
microcirculation, and impaired PA endothelium‐dependent dilation occurs in dementia …
microcirculation, and impaired PA endothelium‐dependent dilation occurs in dementia …