The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

Infections are one of the major selective pressures acting on humans, and host-pathogen
interactions contribute to shaping the genetic diversity of both organisms. Evolutionary …

Human genetic diversity is the result of population genetic forces. This genetic variation
influences disease risk and contributes to health disparities. Autoimmune diseases (ADs) …

The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and
abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors …

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both
humoral and innate immunity and are central to maintaining the balance between …

The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding
immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus …

We have identified a rare healthy FcγRIIIB (CD16B)-null donor completely lacking FCGR3B
RNA and protein expression and dissected the role of the different neutrophil Fcγ receptors …

Variability in the susceptibility to infectious disease and its clinical manifestation can be
determined by variation in the environment and by genetic variation in the pathogen and the …

Reduced FCGR3B copy number is associated with increased risk of systemic lupus
erythematosus (SLE). The five FCGR2/FCGR3 genes are arranged across two highly …