According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons, a
process that current therapeutic approaches cannot prevent. In PD, the typical pathological …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Intrinsically disordered proteins (IDPs) are implicated in many human diseases. They have
generally not been amenable to conventional structure-based drug design, however …

Intrinsically disordered domains represent attractive therapeutic targets because they play
key roles in cancer, as well as in neurodegenerative and infectious diseases. They are …

The accumulation of damaged mitochondria causes the death of dopaminergic neurons.
The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells …

Lewy bodies that contain aggregated α‐synuclein in dopamine neurons are the main culprit
for neurodegeneration in Parkinson's disease. However, mitochondrial dysfunction has a …