Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and
many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

The calcium ion has long been known to play an important role in cell death regulation.
Hence, necrotic cell death was early associated with intracellular Ca 2+ overload, leading to …

Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

Pancreatic cancer is one of the most lethal types of cancer with a mortality rate of almost
95%. Treatment with current chemotherapeutic drugs has limited success due to poor …

Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations,
activating oncogenes, and raising oxidative stress, which all influence cell proliferation …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Both PI3K/AKT/mTOR/S6K1 and mitogen activated protein kinase (MAPK) signaling
cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis …

Prostate cancer is the most commonly diagnosed malignancy among men in industrialized
countries, accounting for the second leading cause of cancer-related deaths. Although we …

An essential advantage during eukaryotic cell evolution was the acquisition of a network of
mitochondria as a source of energy for cell metabolism and contrary to conventional …