Ligands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate
signal transduction through a bewildering complexity of ligand–receptor interactions …

The transforming growth factor ß (TGF-ß) family of hormonally active polypeptides have
attracted much attention because of their ability to control cellular functions that underwrite …

Developing tissues form spatial patterns by establishing concentration gradients of diffusible
signaling proteins called morphogens. The bone morphogenetic protein (BMP) morphogen …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

Skeletal homeostasis is determined by systemic hormones and local factors. Bone
morphogenetic proteins (BMP) are unique because they induce the differentiation of …

Transforming growth factor‐β (TGF‐β) superfamily members are multifunctional cell‐cell
signaling proteins that play pivotal roles in tissue homeostasis and development of …

Myostatin is a transforming growth factor β family member that acts as a negative regulator of
skeletal muscle growth. Myostatin circulates in the blood of adult mice in a noncovalently …

The zebrafish EGF-CFC gene one-eyed pinhead (oep) is required zygotically for the
formation of the ventral neuroectoderm, endoderm, and prechordal plate. Here we report …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the
transforming growth factor‐β (TGFβ) superfamily with significant roles in bone and cartilage …