Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

Super enhancers (SEs) are large clusters of adjacent enhancers that drive the expression of
genes which regulate cellular identity; SE regions can be enriched with a high density of …

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …

Colorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic
options is a pressing issue that needs to be addressed. Here, we established human CRC …

This study investigates aberrant DNA methylations as potential diagnosis and prognosis
markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced …

Esophageal squamous cell carcinomas (ESCCs) harbor recurrent chromosome 3q
amplifications that target the transcription factor SOX2. Beyond its role as an oncogene in …

Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …

Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a
combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed …

One major characteristic of tumor cells is the aberrant activation of epigenetic regulatory
elements, which remodel the tumor transcriptome and ultimately promote cancer …