Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Sirtiun 5 (SIRT5) is a NAD+-dependent protein lysine deacylase primarily located in
mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly …

The mitochondrial SIRT3 modulates several biological pathways such as cancer,
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …

Abstract Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+
(NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative …

Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining
attention for the treatment of different cancer types, but also to contrast neurodegenerative …

Sirtuins are NAD+-dependent protein lysine deacylases and mono-ADP-ribosylases whose
activity regulates different pathways, including DNA damage repair, cell survival and …

Sirtuin 5 (SIRT5) is a predominantly mitochondrial enzyme catalyzing the removal of glutaryl,
succinyl, malonyl, and acetyl groups from lysine residues through a NAD+-dependent …

Sirtuins are NAD+-dependent protein lysine deacylases implicated in aging-related
diseases. Mammalian Sirtuin 4 (Sirt4) is located in mitochondria and a potential therapeutic …

Recent advances in glioblastoma (GB) research have shed light on the molecular
characteristics, the defected intracellular signaling pathways, and the genetic and epigenetic …

Subarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant
global mortality and morbidity rates. Despite advancements in pharmacological and surgical …