The dynamic lung microbiome in health and disease

JG Natalini, S Singh, LN Segal - Nature Reviews Microbiology, 2023 - nature.com
New methods and technologies within the field of lung biology are beginning to shed new
light into the microbial world of the respiratory tract. Long considered to be a sterile …

Lung microbiome: new insights into the pathogenesis of respiratory diseases

R Li, J Li, X Zhou - Signal transduction and targeted therapy, 2024 - nature.com
The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

Stress and stability: applying the Anna Karenina principle to animal microbiomes

JR Zaneveld, R McMinds, R Vega Thurber - Nature microbiology, 2017 - nature.com
All animals studied to date are associated with symbiotic communities of microorganisms.
These animal microbiotas often play important roles in normal physiological function and …

Alterations in the respiratory tract microbiome in COVID-19: current observations and potential significance

C Merenstein, FD Bushman, RG Collman - Microbiome, 2022 - Springer
SARS-CoV-2 infection causes COVID-19 disease, which can result in consequences
ranging from undetectable to fatal, focusing attention on the modulators of outcomes. The …

Pathogenesis of HIV-related lung disease: immunity, infection, and inflammation

SK Cribbs, K Crothers, A Morris - Physiological reviews, 2020 - journals.physiology.org
Despite anti-retroviral therapy (ART), human immunodeficiency virus-1 (HIV)-related
pulmonary disease continues to be a major cause of morbidity and mortality for people living …

[HTML][HTML] Microbiota and lung cancer

T Goto - Seminars in cancer biology, 2022 - Elsevier
Until recently, bacteria have been studied in terms of their roles in infectious diseases and
mainly by using isolation and culture methods. However, in practice, many bacteria existing …

Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung

LN Segal, JC Clemente, BG Wu, WR Wikoff, Z Gao, Y Li… - Thorax, 2017 - thorax.bmj.com
Introduction Azithromycin (AZM) reduces pulmonary inflammation and exacerbations in
patients with COPD having emphysema. The antimicrobial effects of AZM on the lower …

Episodic aspiration with oral commensals induces a MyD88-dependent, pulmonary T-helper cell type 17 response that mitigates susceptibility to Streptococcus …

BG Wu, I Sulaiman, JCJ Tsay, L Perez… - American journal of …, 2021 - atsjournals.org
Rationale: Cross-sectional human data suggest that enrichment of oral anaerobic bacteria in
the lung is associated with an increased T-helper cell type 17 (Th17) inflammatory …

Methods in lung microbiome research

SM Carney, JC Clemente, MJ Cox… - American journal of …, 2020 - atsjournals.org
The lung microbiome is associated with host immune response and health outcomes in
experimental models and patient cohorts. Lung microbiome research is increasing in …

Anaerobic bacterial fermentation products increase tuberculosis risk in antiretroviral-drug-treated HIV patients

LN Segal, JC Clemente, Y Li, C Ruan, J Cao… - Cell host & …, 2017 - cell.com
Despite the immune-reconstitution with antiretroviral therapy (ART), HIV-infected individuals
remain highly susceptible to tuberculosis (TB) and have an enrichment of oral anaerobes in …