The kynurenine pathway of tryptophan degradation generates several neuroactive
compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 …

With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia
affects the most basic human processes of perception, emotion, and judgment. Evidence …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

Adult neurogenesis occurs throughout life in discrete regions of the adult mammalian brain.
Little is known about the mechanism governing the sequential developmental process that …

The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

It has been conventional for psychiatric research, including the search for predisposing
genes, to proceed under the assumption that schizophrenia and bipolar disorder are …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …

Abstract 22q11. 2 deletion syndrome (22qDS) is a genetic syndrome associated with a
chromosome 22q11. 2 deletion and variable phenotypic expression that commonly includes …

Schizophrenia is widely held to stem from the combined effects of multiple common
polymorphisms, each with a small impact on disease risk. We suggest an alternative view …

Genetic epidemiological studies suggest that individual variation in susceptibility to
schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple …