Spatial architecture of the cochlear immune microenvironment in noise-induced and age-related sensorineural hearing loss

P Li, T Qian, S Sun - International Immunopharmacology, 2023 - Elsevier
The cochlea encodes sound stimuli and transmits them to the central nervous system, and
damage to sensory cells and synapses in the cochlea leads to hearing loss. The inner ear …

Signaling pathways regulating the immune function of cochlear supporting cells and their involvement in cochlear pathophysiology

Y Hayashi - Glia, 2024 - Wiley Online Library
The inner ear, including the cochlea, used to be regarded as an immune‐privileged site
because of its immunologically isolated environment caused by the blood‐labyrinthine …

[HTML][HTML] Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal

M Hosoya, T Kitama, MN Shimanuki… - Frontiers in …, 2023 - frontiersin.org
Introduction Macrophages are essential immune cells in the cochlea that contribute to
inflammation, tissue repair, and homeostasis. They also play an important role in local …

Complement factor B is essential for the proper function of the peripheral auditory system

LSN Brown, JL Barth, S Jafri, JA Rumschlag… - Frontiers in …, 2023 - frontiersin.org
Sensorineural hearing loss is associated with dysfunction of cochlear cells. Although
immune cells play a critical role in maintaining the inner ear microenvironment, the precise …

Kölliker's organ-supporting cells and cochlear auditory development

J Chen, D Gao, L Sun, J Yang - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
The Kölliker's organ is a transient cellular cluster structure in the development of the
mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal …

Research Advancements in the Interplay between T3 and Macrophages

L Yang, M Fu, H Wang, H Sun - Current Medical Science, 2024 - Springer
Abstract 3, 3′, 5-Triiodo-L-thyronine (T3) is a key endocrine hormone in the human body
that plays crucial roles in growth, development, metabolism, and immune function …

Macrophages allocate before apoptosis initiation and produce reactive oxygen species during interdigital phagocytosis

D Hernández-García, C García-Meléndrez… - Biology …, 2024 - journals.biologists.com
During programmed cell death (PCD), it is commonly accepted that macrophages are
recruited by apoptotic cells to complete cell degradation. Interdigital cell death, a classical …

Store-Operated Ca2+ Channels Contribute to the Generation of Ca2+ Waves in Interdental Cells in the Cochleae

Q Ma, J Zhang, W Qi, Z Li, Y Jiang… - ACS Chemical …, 2023 - ACS Publications
Cochlear calcium (Ca2+) waves are vital regulators of the cochlear development and
establishment of hearing function. Inner supporting cells are believed to be the main region …

The Dual Roles of Triiodothyronine in Regulating the Morphology of Hair Cells and Supporting Cells during Critical Periods of Mouse Cochlear Development

X Bai, K Xu, L Xie, Y Qiu, S Chen, Y Sun - International Journal of …, 2023 - mdpi.com
Clinically, thyroid-related diseases such as endemic iodine deficiency and congenital
hypothyroidism are associated with hearing loss, suggesting that thyroid hormones are …

Development of semicircular canal occlusion

S Fei, L Guangfei, M Jie, G Yiling, C Mingjing… - Frontiers in …, 2022 - frontiersin.org
Surgical treatment of vertigo is performed with in-depth study of inner ear diseases.
Achieving an effective control of vertigo symptoms while reducing damage to hearing and …