Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

The advent of modern antimicrobial therapy following the discovery of penicillin during the
1940s yielded remarkable improvements in case fatality rate of serious infections including …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Introduction Despite evidence demonstrating the value of performance initiatives, marked
differences remain between hospitals in the delivery of care for patients with sepsis. The …

BACKGROUND: In this study, our objective was to determine whether a perioperative
hemodynamic protocol based on noninvasive cardiac output monitoring decreases the …

Introduction Outcome studies in patients with acute kidney injury (AKI) have focused on
differences between modalities of renal replacement therapy (RRT). The outcome of …

Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical
practice, plus the increasing awareness that certain processes of care associated with …

Objectives To evaluate whether the timing of initial antibiotic administration in patients with
sepsis in hospital affects mortality. Methods This systematic review and meta-analysis …

PURPOSE: The reported actual compliance for severe sepsis bundles was very low,
suggesting the presence of barriers to their implementation. The purpose of this study was to …

Abstract Background: The Surviving Sepsis Campaign (SSC) was launched in 2002 as a
collaborative initiative of the European Society of Intensive Care Medicine (ESICM), the …