Estrogen receptors and signaling in fibroids: role in pathobiology and therapeutic implications

MA Borahay, MR Asoglu, A Mas, S Adam… - Reproductive …, 2017 - journals.sagepub.com
Uterine fibroids are the most common gynecologic tumors with a significant medical and
financial burden. Several genetic, hormonal, and biological factors have been shown to …

The mechanism and function of epigenetics in uterine leiomyoma development

Q Yang, A Mas, MP Diamond… - Reproductive …, 2016 - journals.sagepub.com
Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …

The management of uterine leiomyomas

GA Vilos, C Allaire, PY Laberge, N Leyland… - Journal of Obstetrics and …, 2015 - Elsevier
Objectives The aim of this guideline is to provide clinicians with an understanding of the
pathophysiology, prevalence, and clinical significance of myomata and the best evidence …

1, 25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model

SK Halder, C Sharan, A Al-Hendy - Biology of reproduction, 2012 - academic.oup.com
Uterine leiomyomas (fibroids) are the most common benign tumors in women of
reproductive age. These tumors are three to four times more prevalent in African American …

Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study

M Sabry, SK Halder, ASA Allah, E Roshdy… - … journal of women's …, 2013 - Taylor & Francis
Purpose Currently there is no effective medicinal treatment for uterine fibroids (UFs), a
common health disorder that affects women of reproductive age. Identification of modifiable …

Uterine fibroids: clinical manifestations and contemporary management

L Doherty, L Mutlu, D Sinclair… - Reproductive …, 2014 - journals.sagepub.com
Uterine fibroids (leiomyomata) are extremely common lesions that are associated with
detrimental effects including infertility and abnormal uterine bleeding. Fibroids cause …

Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis

S Zhou, T Yi, R Liu, C Bian, X Qi, X He, K Wang… - Molecular & cellular …, 2012 - ASBMB
Adenomyosis is a common estrogen-dependent disorder of females characterized by a
downward extension of the endometrium into the uterine myometrium and …

Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis

PC Huang, EM Tsai, WF Li, PC Liao… - Human …, 2010 - academic.oup.com
BACKGROUND Phthalates are known to have estrogenic effects in cell models and
experimental animals. However, the evidence regarding the effects of phthalates on human …

Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study

E Roshdy, V Rajaratnam, S Maitra… - … journal of women's …, 2013 - Taylor & Francis
Background Uterine fibroids (UFs, also known as leiomyoma) affect 70% of reproductive-
age women. Imposing a major burden on health-related quality-of-life (HRQL) of …

Role of medical management for uterine leiomyomas

BN Kashani, G Centini, SS Morelli, G Weiss… - Best Practice & …, 2016 - Elsevier
Highlights•Medical management should be considered as an alternative to surgery in the
management of fibroids.•Selection of medical management should be based on a patient's …