Fatty acid metabolism contributes to energy supply and plays an important role in regulating
immunity. Free fatty acids (FFAs) bind to free fatty acid receptors (FFARs) on the cell surface …

Functional impairments in the brain's insulin and insulin-like growth factor (IGF) signal
transduction networks are recognized mediators of dysregulated energy metabolism, a …

Background The complex pathophysiology of epilepsy hampers the development of effective
treatments. Although more than ten kinds of anti-seizures drugs (ASDs) have good effects on …

Coptisine (Cop) exerts a neuroprotective effect on central nervous system disease,
particularly ischemic stroke. However, its protective mechanism is still unclear. This study …

Metabolic syndrome (MetS) is closely associated with an increased risk of dementia and
cognitive impairment, and a complex interaction of genetic and environmental dietary factors …

G protein-coupled receptor 120 (GPR120, Ffar4) is a sensor for long-chain fatty acids
including omega-3 polyunsaturated fatty acids (n-3 PUFAs) known for beneficial effects on …

Lipid dyshomeostasis and neuroinflammation are key hallmarks of neuropsychiatric and
neurodegenerative disorders, including major depressive disorder and Alzheimer's disease …

Prostaglandins (PGs) play a crucial and multifaceted role in various physiological processes
such as intercellular signaling, inflammation regulation, neurotransmission, vasodilation …

The global burden of neurological disorders is evident, yet there remains limited efficacious
therapeutics for their treatment. There is a growing recognition of the role of inflammation in …

Loquat (Eriobotrya japonica) leaves contain many bioactive components such as ursolic
acid (UA) and amygdalin. We investigated the effects of loquat leaf powder and methanol …