A Tandem Madelung Indole Synthesis Mediated by a LiN(SiMe3)2/CsF System

R Ma, YE Wang, D Xiong, J Mao - Organic Letters, 2023 - ACS Publications
A tandem Madelung indole synthesis by the reaction of methyl benzoate and N-methyl-o-
toluidine has been discovered. The combination of LiN (SiMe3) 2 with CsF is the key factor …

Diselenides and selenocyanates as versatile precursors for the synthesis of pharmaceutically relevant compounds

MD Kostić, VM Divac - Current Organic Synthesis, 2022 - ingentaconnect.com
Organoselenium chemistry has undergone extensive development during the past decades,
mostly due to the unique chemical properties of organoselenium compounds that have been …

[HTML][HTML] Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues

K Flouda, B Gammelgaard, MJ Davies, CL Hawkins - Redox Biology, 2021 - Elsevier
The production of hypochlorous acid (HOCl) by myeloperoxidase (MPO) plays a key role in
immune defense, but also induces host tissue damage, particularly in chronic inflammatory …

Seleno-indoles trigger reactive oxygen species and mitochondrial dysfunction in Leishmania amazonensis

PC Santana Filho, MB da Silva, BNM da Silva, T Fazolo… - Tetrahedron, 2023 - Elsevier
Leishmaniasis is an endemic disease caused by obligate intracellular protozoa of the genus
Leishmania prevalent in the Americas, Africa, and Asia. Therapeutic options are limited for …

Synthesis of 3-chalcogenyl-indoles mediated by the safer reagent urea-hydrogen peroxide (UHP)

JR Menezes, MM Gularte, FC dos Santos, JA Roehrs… - Tetrahedron …, 2023 - Elsevier
Herein, we report the use of urea-hydrogen peroxide (UHP) as an oxidizing agent in the
direct C3 chalcogenylation of indoles with diorganyl dichalcogenides, in the presence of an …

New 8-hydroxyquinoline derivatives highlight the potential of this class for treatment of fungal infections

AR Joaquim, P Reginatto, MS Lopes… - New Journal of …, 2021 - pubs.rsc.org
The oral administration of clioquinol–a potent 8-hydroxyquinoline antimicrobial drug–was
forbidden due to suspicion of it being the cause of SMON (subacute myelo-optic …

Theoretical Investigation of Cyano‐Chalcogen Dimers and Their Importance in Molecular Recognition

V Previtali, G Sánchez‐Sanz, C Trujillo - ChemPhysChem, 2019 - Wiley Online Library
In this manuscript the different noncovalent interactions established between (HYCN) 2
dimers (Y= S, Se and Te) have been studied at the MP2 and CCSD (T) level of theory …

Solid‐State Direct Electrophilic Selenocyanation of (Hetero) Arenes using Mechanochemistry

JA Xiao, JS Liang, H Zhang, RF Meng… - European Journal of …, 2022 - Wiley Online Library
A mechanochemical direct selenocyanation of arenes/heterocyclic arenes with electrophilic
selenocyanating reagents to access (hetero) aryl selenocyanates has been developed. This …

[HTML][HTML] Selenocyanate (SeCN−) acts as an efficient competitive substrate for myeloperoxidase and decreases biological damage induced by hypochlorous acid

X Zhang, S Xu, CY Chuang, BJ Day… - Redox Biochemistry and …, 2024 - Elsevier
The leukocyte-derived enzyme myeloperoxidase (MPO) is a key component of the innate
immune response and mediates the killing of pathogens via the generation of the powerful …

Synthesis of Selenocyanated Indoles via PhICl2‐Induced Electrophilic Intramolecular Cyclization of 2‐Alkynylanilines or 2‐Alkenylanilines

L Xu, B Zhao, H Zhao, J Zhang, J Li… - Asian Journal of Organic …, 2024 - Wiley Online Library
The 3‐selenocyanato‐substituted indoles were readily synthesized via (dichloroiodo)
benzene (PhICl2)‐induced reaction of 2‐alkynylanilines or 2‐alkenylanilines with KSeCN in …