The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Chemokines are a group of about 50 chemotactic cytokines crucial for the migration of
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …

The transmission of cellular information requires fine and subtle regulation of proteins that
need to interact in a coordinated and specific way to form efficient signaling networks. The …

To date, X-ray crystallography remains the gold standard for the determination of
macromolecular structure and protein substrate interactions. However, the unpredictability of …

The development of multicellular organisms depends on cell adhesion molecules (CAMs)
that connect cells to build tissues. The immunoglobulin superfamily (IgSF) constitutes one of …

Bone marrow-derived endothelial progenitor cells (EPCs) contribute to neovessel formation
in response to growth factors, cytokines, and chemokines. Chemokine receptor CXCR2 and …

Four phospholipase C β (PLCB) isoforms, PLCB1, PLCB2, PLCB3 and PLCB4, have been
previously investigated regarding their roles in the metabolism of inositol lipids and cancer …

The phosphoinositide‐specific phospholipase C (PLC) enzyme family consists of six classes
of proteins that hydrolyze membrane phosphoinositides in response to various stimuli …

Na+/H+ exchanger regulatory factor 1 (NHERF1; also known as ezrin-radixin-moesin–
binding phosphoprotein 50) is a PSD-95, disc large, zona occludens-1 adapter that acts as a …

Pancreatic cancer (PC) is a highly malignant tumor derived from pancreas tissue and is one
of the leading causes of death from cancer. Its molecular mechanism has been partially …