N‐Methylation is one of the simplest chemical modifications often occurring in peptides and
proteins of prokaryotes and higher eukaryotes. Over years of evolution, nature has …

Successful mapping of the human genome has sparked a widespread interest in
deciphering functional information encoded in gene sequences. However, because of the …

Ubiquitination-dependent histone crosstalk plays critical roles in chromatin-associated
processes and is highly associated with human diseases. Mechanism studies of the …

The eukaryotic genome is packaged into a complex of DNA and proteins called chromatin.
The fundamental repeating unit of chromatin, the nucleosome, consists of an octamer of …

Protein methyltransferases (PMTs) play various physiological and pathological roles through
methylating histone and nonhistone targets. However, most PMTs including more than 60 …

One of the rising demands in the field of protein chemical synthesis is the development of
facile strategies that yield the protein in workable quantities and homogeneity, with fewer …

Histones, the major protein components of chromatin, are extensively altered by
posttranslational modifications (PTMs). Deciphering distinctive patterns of these PTMs …

Abstract The BRAF V600E mutation causes impaired expression of sodium iodide symporter
(NIS) and radioiodine refractoriness of thyroid cancer, but the underlying mechanism …

The structure of eukaryotic chromatin directly influences gene function, and is regulated by
chemical modifications of the core histone proteins. Modification of the human histone H4 N …

Chromatin folding and dynamics are critically dependent on nucleosome–nucleosome
interactions with important contributions from internucleosome binding of the histone H4 N …