Alphaherpesviruses, as large double-stranded DNA viruses, were long considered to be
genetically stable and to exist in a homogeneous state. Recently, the proliferation of high …

Herpes simplex viruses (HSV) cause chronic infection in humans that are characterized by
periodic episodes of mucosal shedding and ulcerative disease. HSV causes millions of …

Genomic rearrangements contribute to the enhancement of genetic diversity in populations.
However, non-canonical rearrangements (NCRs) such as deletions, insertions, and …

The viral intra-host genetic diversities and interactions with the human genome during
decades of persistence remain poorly characterized. In this study, we analyzed the …

Herpes simplex virus (HSV) causes chronic infection in the human host, characterized by
self-limited episodes of mucosal shedding and lesional disease, with latent infection of …

Abstract Herpes Simplex Virus type 1 (HSV-1) chronically infects over 70 per cent of the
global population. Clinical manifestations are largely restricted to recurrent epidermal …

Herpes simplex virus 1 (HSV1) is best known for causing oral lesions and mild clinical
symptoms, but it can produce a significant range of disease severities and rates of …

Herpes simplex virus (HSV) infection of the neonatal brain causes severe encephalitis and
permanent neurologic deficits. However, infants infected with HSV at the time of birth follow …

Deaths from herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2)
are rare. A major exception is perinatally acquired HSV-1 or HSV-2 infection where the …

Background Herpes simplex virus 1 (HSV-1) is considered the primary cause of Labial
herpes. The primary diagnostic approach for HSV type is polymerase chain reaction (PCR) …