Cellular cytotoxicity, the ability to kill other cells, is an important effector mechanism of the
immune system to combat viral infections and cancer. Cytotoxic T cells and natural killer …

Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

In breast cancer, genetic heterogeneity, the lack of actionable targets and immune evasion
all contribute to the limited clinical response rates to immune checkpoint blockade therapy …

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

Background The role of tumor-infiltrating immune cells in the early metastatic invasion of
colorectal cancer is unknown. Methods We studied pathological signs of early metastatic …

Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to
eliminate virus-infected or transformed cells. Studies in gene-disrupted mice indicate that …

Cytotoxic T lymphocytes (CTLs) provide potent defences against virus infection and
intracellular pathogens. However, CTLs have a dark side—their lytic machinery can be …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

Natural killer (NK) cells are innate effector lymphocytes necessary for defence against
stressed, microbe-infected, or malignant cells. NK cells kill target cells by either of two major …