Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …

Understanding the biology of prostate cancer metastasis has been limited by the lack of
tissue for study. We studied the clinical data, distribution of prostate cancer involvement …

The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a
lethal event of uncertain molecular etiology. Comparing gene expression in isogenic …

Relapse of prostate cancer after androgen ablation therapy is hormone-refractory, with
continued tumor growth being dependent on the androgen receptor (AR). E2F-1, a regulator …

MicroRNAs (miRNA) have been globally profiled in cancers but there tends to be poor
agreement between studies including in the same cancers. In addition, few putative miRNA …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men.
Hormone-refractory invasive PCa is the end stage and accounts for the majority of PCa …

A high intake of fruits and vegetables is associated with a lower risk of cancer. In this context,
considerable attention is paid to Asian populations who consume high amounts of soy and …

An increase in the activity of mitogen-activated protein kinase (MAPK) has been correlated
with the progression of prostate cancer to advanced disease in humans. The …

Developmental studies of the prostate have established that ductal morphogenesis,
epithelial cytodifferentiation, and proliferation/apoptosis are regulated by androgens acting …