The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …

Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ)
contribute to Alzheimer's disease (AD) pathology. APOE 4 is the greatest AD‐genetic risk …

Background Aging is accompanied by increasing vulnerability to pathologies such as
atherosclerosis (ATH) and Alzheimer disease (AD). Are these different pathologies, or …

Microglia affect Alzheimer's disease (AD) pathogenesis in opposing manners, by protecting
against amyloid accumulation in early phases of the disease and promoting neuropathology …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, the main
pathological hallmark of which is the loss of neurons, resulting in cognitive and memory …

As the main immune cells of the central nervous system (CNS), microglia regulates normal
development, homeostasis and general brain physiology. These functions put microglia at …

Abstract Alzheimer's disease (AD), the most common type of dementia worldwide, is
characterized by high levels of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein …

Apolipoprotein E (ApoE) plays crucial roles not only in lipid metabolism but also in bone
metabolism. Specifically ApoE4, one of major ApoE isoforms, has been demonstrated to be …

Several lines of evidence support immune response in brain as a mechanism of injury in
Alzheimer disease (AD). Moreover, immune activation is heightened in apolipoprotein E …