Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Influence of glutamate and GABA transport on brain excitatory/inhibitory balance
SMS Sears, SJ Hewett - Experimental Biology and Medicine, 2021 - journals.sagepub.com
An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …
Enantiomer-dependent immunological response to chiral nanoparticles
Chirality is a unifying structural metric of biological and abiological forms of matter. Over the
past decade, considerable clarity has been achieved in understanding the chemistry and …
past decade, considerable clarity has been achieved in understanding the chemistry and …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
Ionotropic glutamate receptors (iGluRs) mediate neuronal communication at synapses
throughout vertebrate and invertebrate nervous systems. We have characterized a family of …
throughout vertebrate and invertebrate nervous systems. We have characterized a family of …
Ionotropic GABA and glutamate receptor mutations and human neurologic diseases
The advent of whole exome/genome sequencing and the technology-driven reduction in the
cost of next-generation sequencing as well as the introduction of diagnostic-targeted …
cost of next-generation sequencing as well as the introduction of diagnostic-targeted …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
GluD1 binds GABA and controls inhibitory plasticity
Fast synaptic neurotransmission in the vertebrate central nervous system relies primarily on
ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A γ …
ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A γ …
D-Serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor
W Kakegawa, Y Miyoshi, K Hamase, S Matsuda… - Nature …, 2011 - nature.com
Abstract d-Serine (d-Ser) is an endogenous co-agonist for NMDA receptors and regulates
neurotransmission and synaptic plasticity in the forebrain. d-Ser is also found in the …
neurotransmission and synaptic plasticity in the forebrain. d-Ser is also found in the …