SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

▪ Abstract ATP-binding cassette (ABC) transporters couple ATP hydrolysis to the uptake and
efflux of solutes across the cell membrane in bacteria and eukaryotic cells. In bacteria, these …

Recent advances in large-scale sequencing has accelerated the identification of potential
genes. To find the function of these genes, the homology search technique has been …

Type I secretion systems exist in monoderm (surrounded by a single membrane) Gram-
positive bacteria and diderm (containing both an inner cytoplasmic membrane and an outer …

HasASM secreted by the Gram-negative bacterium Serratia marcescens belongs to the
hemophore family. Its role is to take up heme from host heme carriers and to shuttle it to …

A very large type I polypeptide begins to reel out from a ribosome; minutes later, the still
unidentifiable polypeptide, largely lacking secondary structure, is now in some cases a …

Type I secretion systems are widespread in Gram-negative bacteria and mediate the one-
step translocation of a large variety of proteins serving for diverse purposes, including …

For translocation across the cell envelope of Gram-negative bacteria, substances have to
overcome two permeability barriers, the inner and outer membrane. Channel-tunnels are …

The HasASM hemophore, secreted by Serratia marcescens, binds free or hemoprotein
bound heme with high affinity and delivers it to a specific outer membrane receptor, HasR. In …

Hemophore HasA is a 19 kDa iron (III) hemoprotein that participates in the shuttling of heme
to a specific membrane receptor. In HasA, heme iron has an original coordination …