Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …

Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …

Ionizable cationic lipid-containing lipid nanoparticles (LNPs) are the most clinically
advanced non-viral gene delivery platforms, holding great potential for gene therapeutics …

With three FDA-approved products, lipid nanoparticles (LNPs) are under intensive
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …

Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …

MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors, capable of up or down‐
regulating gene expression during tumorigenesis; they are diagnostic biomarkers or …

Hepatocellular carcinoma (HCC) is a prevalent and lethal disease, and tumor regression
rarely occurs in advanced HCC patients due to limited effective therapies. Given the …

Lipid nanoparticles (LNPs) have proven to be promising delivery vehicles for RNA-based
vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic …

Advances in lipid nanoparticle (LNP) design have contributed notably to the emergence of
the current clinically approved mRNA-based vaccines and are of high relevance for …

Optical image sensors are 2D arrays of pixels that integrate semiconductor photodiodes and
field effect transistors for efficient photon conversion and processing of generated electrons …