Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity

AV Zaytsev, JE Mick, E Maslennikov… - Molecular Biology of …, 2015 - Am Soc Cell Biol
Microtubule (MT) attachment to kinetochores is vitally important for cell division, but how
these interactions are controlled by phosphorylation is not well known. We used quantitative …

Biophysics of microtubule end coupling at the kinetochore

EL Grishchuk - Centromeres and Kinetochores: Discovering the …, 2017 - Springer
The main physiological function of mitotic kinetochores is to provide durable attachment to
spindle microtubules, which segregate chromosomes in order to partition them equally …

Accurate phosphoregulation of kinetochore–microtubule affinity requires unconstrained molecular interactions

AV Zaytsev, LJR Sundin, KF DeLuca… - Journal of Cell …, 2014 - rupress.org
Accurate chromosome segregation relies on dynamic interactions between microtubules
(MTs) and the NDC80 complex, a major kinetochore MT-binding component …

Strain stiffening of Ndc80 complexes attached to microtubule plus ends

F Schwietert, VA Volkov, PJ Huis, M Dogterom… - Biophysical …, 2022 - cell.com
In the mitotic spindle, microtubules attach to chromosomes via kinetochores. The
microtubule-binding Ndc80 complex is an integral part of kinetochores, and is essential for …

Bistability and oscillations in cooperative microtubule and kinetochore dynamics in the mitotic spindle

F Schwietert, J Kierfeld - New journal of physics, 2020 - iopscience.iop.org
In the mitotic spindle microtubules attach to kinetochores via catch bonds during metaphase,
and microtubule depolymerization forces give rise to stochastic chromosome oscillations …

Electrostatic forces drive poleward chromosome motions at kinetochores

L John Gagliardi, DH Shain - Cell Division, 2016 - Springer
Abstract Background Recent experiments regarding Ndc80/Hec1 in force generation at
kinetochores for chromosome motions have prompted speculation about possible models …

Mathematical modeling of spatiotemporal protein localization patterns in C. crescentus bacteria: A mechanism for asymmetric FtsZ ring positioning

B Shtylla - Journal of theoretical biology, 2017 - Elsevier
We examine the localization patterns of ParA, ParB, PopZ, and MipZ, which are key division
proteins in C. crescentus bacteria. While Par and PopZ proteins have been implicated in the …

Molecular force spectroscopy of kinetochore-microtubule attachment in silico: Mechanical signatures of an unusual catch bond and collective effects

D Ghanti, S Patra, D Chowdhury - Physical Review E, 2018 - APS
Measurement of the lifetime of attachments formed by a single microtubule (MT) with a
single kinetochore (kt) in vitro under force-clamp conditions had earlier revealed a catch …

[PDF][PDF] Dynamics and forces in the mitotic spindle

F Schwietert - 2022 - eldorado.tu-dortmund.de
Microtubules are cylindrical cytoskeletal filaments. Their polymerization dynamics is
characterized by a dynamic instability between phases of growth and shrinkage. The …

Tensile properties and associated cellular composition of axon bundles in the desert locust and other orthopteroid insects

S Lyons - 2019 - sussex.figshare.com
Axons are known to be under tension during growth and development for guidance of the
growth cone, synapse formation and stretch growth. Tension is also present during …